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- Bridging from the single cell to the cell population – Epo-induced cellular responses and erythroleukemia
- Deciphering tumor microenvironment interactions determining lung cancer development
- Mechanisms controlling the compensation of liver injury and towards model-based biomarkers for early detection of liver cancer
- Application of dynamic pathway modelling for personalized medicine
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The role of EBV infection in the pathogenesis of multiple sclerosis: the BEHIND-MS consortium
Project leader:
Multiple sclerosis (MS) is a neurological disease in which the immune system irreversibly damages the myelin layer in the brain and spinal cord, potentially leading to serious consequences such as paralysis or severe visual impairment. Recent work by Bjornevik and colleagues (Bjornevik et al., Science 2022) has demonstrated the causal link between EBV infection and the development of multiple sclerosis, confirming previous reports that showed infectious mononucleosis as a risk factor for MS. However, despite the many proposed roles played by EBV in the pathogenesis of this neurodegenerative autoimmune condition, limited evidence is currently available.
Our laboratory, in partnership with other 10 research groups across Europe, has received funding in the frame of the Horizon Europe Programme to shed new light on how EBV interaction with the host can promote the development of MS. The BEHIND MS Consortium, with our group as coordinator, by bringing together complementary expertise, will investigate in vitro, ex vivo, and in vivo the mechanisms underlying the pathogenic role of EBV in multiple sclerosis, with the goal of identifying new druggable therapeutic targets and biomarkers to improve diagnose, staging and treatment of this yet-incurable disease.